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Difficile. Although GDH is sensitive, it is not as specific for CDI, because this enzyme is produced by both toxigenic and non-toxigenic organisms. Additionally, antibodies against C. The sensitivity of GDH antigen detection has led to its use as a screening test as part of CDI testing algorithms, although it should be noted that as many as 10 of patients with toxigenic organisms can be missed by this method.
In this approach, GDH is the initial test, and GDH-negative specimens are reported as negative with no further testing done.